Such mutations in CDH1 lead to the loss or dysfunction of E-cadherin, thereby facilitating cancer cell invasion and metastasis ( The initiation and progression of GC involve multiple genetic alterations that collectively disrupt key processes such as proliferation, apoptosis, metabolism, and genomic stability, driving malignancy
[DOI] [PMC free article] [PubMed] [Google Scholar] Yoon J., Moon S.J., Lee K., Yoon S.H., Jang I., Yu K., Lee S
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The protective effect of combining GLP-1 RA therapy with exercise has been previously reported, with Sandsdal et al